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Research Institute of Medical Genetics SB RAMS
Address:
10 Nab. Ushaiki, Tomsk 634050, RUSSIA
Phone:
Приемная директора:
+7 (3822) 51-22-28;

Генетическая клиника
Адрес:
г.Томск, Московский тракт, 3 Регистратура:
+7 (3822) 53-05-37

Fax: +7 (3822) 51-37-44

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02.06.2010  
Public attitudes towards predictive genetic testing in Russia has been published in a Journal of Personalized Medicine №7 incoming in the collection of Journals of Future Medicine
Public attitudes towards predictive genetic testing in Russia has been published in a Journal of Personalized Medicine №7 incoming in the collection of Journals of Future Medicine
The article is available in Publication section:
Makeeva OA, Markova VV, Roses AD, Puzyrev VP: An epidemiologic-based survey of public attitudes towards predictive genetic testing in Russia. Pers. Med. 7(3), 291-300 (2010).
Genetic testing for common diseases has become one of the most controversial topics present in the recent genetics literature. Many genetic tests are becoming available direct-to-consumers before critical medical implications have been widely considered. High level of public interest as well as overestimated expectations is one of factors that determine the rapid development of personal genome services. In a Russian urban population, 85% of 2000 respondents answered positively to a question about their own willingness to undergo predictive genetic testing for preventable health conditions and 88.5% of surveyed people said that they would change their life style in case of high risk detection. But the genetic discrimination causes some concerns in 48% of surveyed respondents. Gender, age and health status significantly influenced response. The most important reason to be tested is a concern about health but refuse to be tested is connected with the difficulty to pay for it and after treatment.

A high rate of acceptance of genetic testing was revealed in Finnish population: approximately 90% agreed that genetic testing should be available to everyone who wants to know whether he or she carries disease genes as well as 59% of Germans. In Britain, 69% of people expressed their interest in being tested for genetic susceptibility to cardiovascular diseases, and 64% expressed interest in susceptibility to cancer. Other survey revealed that 81% of British could have undergone genetic testing if it was recommended by the doctor. In the USA, 81% of female population agreed that testing for breast cancer should be recommended to all women. A survey conducted in 6 European countries, reviled that 66% of 6000 respondents would like to undergo genetic testing in order to choose their personal diet.  
Highly overestimated expectations encountered in many studies along with the low predictive capacity of present DNA tests result in negative consequences (psychological stress, unnecessary medical interventions). However, it was revealed in several studies that any psychological harm is low and can be addressed by proper counseling.  
Authors of the article note that here is a need for prospective validation of genetic panels for risk assessments and for efforts to measure the effects of genetic information disclosure and how this information might contribute to lifestyle changes. OPAL (Opportunity for the Prevention of Alzheimer’s Disease) is one of the examples of the prospective clinical studies which focused on approbation of the genetic panel. New drug for predicting the age of Alzheimer’s disease onset will be investigated.

 
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