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Research Institute of Medical Genetics SB RAMS
Address:
10 Nab. Ushaiki, Tomsk 634050, RUSSIA
Phone:
Приемная директора:
+7 (3822) 51-22-28;

Генетическая клиника
Адрес:
г.Томск, Московский тракт, 3 Регистратура:
+7 (3822) 53-05-37

Fax: +7 (3822) 51-37-44

Яндекс.Метрика





 

 

 Laboratory of Evolutionary Genetics

Established in 2000.
Headed by Vadim Anatolevich Stepanov, Doctor of Biological Sciences 

Main research fields:

The principle area of the laboratory is the study of genetic diversity of human populations and ethnogenomics.   

Professor Vadim A. Stepanov

Laboratory staff

Main results:

  • It has been found that, in genetic characteristics,ethnic groups of Northern Eurasia can be divided into several distinct clusters which reflect their common origin and, as a consequence, gene pool closeness; 
  • Genetic dating for the beginning of colonization of the Siberian territory by modern humans has been obtained. It has been shown that genetic diversity generation of studied populations is generally connected with post-glacial recolonization of the territory, which started about 15000 years ago;
  • Phylogeographic analysis of the Y-chromosome lineages (haplogroups) distribution of the Old World territory has been carried out, and its results have supported the evidence for the hypothesis of recent African origin of modern humans. Specific haplogroups have been revealed, which mark the further expansion of modern populations of Asia, Europe, Oceania and migration to the New World;
  • Evidences of genetic history of the region have been discovered, which are indicative of several paleolithic migrations from the territory of West Asia, Western Eurasia, and East Asia in the periods both before and after the maximum of the last glacial period, as well as later migrations of populations in the late Stone Age;
  • Haplotypes structure and evolution as well as the character of linkage disequilibrium in several human genome loci have been revealed.
  • Investigation of the linkage disequilibrium structure, haplotypes evolution, and genetic diversity of human genome fragments of different sites in Eurasian populations;
  • Genetic reconstruction of expansion processes in human populations and analysis of genetic  relationships and origin of Northern Eurasia populations;
  • Molecular ethnogenetics of population of this territory. 

The Laboratory has a wide range of modern genetic technologies, including sequencing, multilocus microsatellites genotyping by means of capillary gel electrophoresis, PCR-RFLP analysis, allele-specific amplification, oligonucleotide-ligase analysis.

The structure and evolution of gene pools are studied using different systems of genetic markers: SNP, Alu mobile genetic elements, autosomal microsatellites, Y-chromosome compound haplotypes, and candidate genes of common diseases.

Research of the Laboratory has been supported by grants of the Russian Foundation for Basic Research (5 research grants and 5 grants for research expeditions), Purpose-Oriented Scientific and Technical Program “Research and Development in Priority Fields of Science and Technology” (4 grants), grants of the President of the Russian Federation, the International Wenner-Gren Foundation, and Administration of the Tomsk Region.
It has been published about 200 research papers. These results were reported at different conferences, meetings, and symposium, such as International Human Genetics Congress, European Human Genetics Conference, International Human Genome Conference, and Genome Variety and Complex Diseases Conference.
Scientific expeditions were organized and hold by the laboratory staff for study the gene pool of populations in different regions of Siberia and Far East: Khanty-Mansi Autonomous Area, Republic of Altai, Republic of Buryatiya, Republic of Khakassiya, and Primorskii Krai.
The Laboratory closely cooperates with Russian research teams from Moscow, Novosibirsk, Ufa, Ulan-Ude, Vladivostok, Novokuznetsk, Yakutsk, Kyzyl, Abakan and international collaboration with colleagues from Australia, Germany, Moldova, Finland, and Estonia. 

 

 


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